Mitochondria: adenine nucleotide transport basics
Contact: Dr. Christos Chinopoulos MD, PhD chinopoulos.christos@eok.sote.hu


The adenine nucleotide translocase (ANT) catalyzes the reversible exchange of ADP for ATP with a 1:1 stoichiometry across the inner mitochondrial membrane. It is the most abundant among mitochondrial carrier family proteins, and in the heart it accounts for as much as 10% of all inner mitochondrial membrane proteins (Nury et al., 2006), (Pebay-Peyroula and Brandolin, 2004). In humans, there are 4 known isoforms (Palmieri, 2004), (Dolce et al., 2005), all encoded by nuclear DNA (Dahout-Gonzalez et al., 2006), (Nury et al., 2006).

For an exhaustive assessment regarding adenine nucleotide exchange through the ANT, the reader is referred to a review by THE authority of the field, Prof. em. Martin Klingenberg, entitled "The ADP and ATP transport in mitochondria and its carrier".
If the reader is more interested in historical aspects regarding the elucidation of ADP-ATP exchange by the ANT, see "Wanderings in bioenergetics and biomembranes", also by M Klingenberg.